Ditropan, Robinol, Probanthine excessive sweating treatments oral medications, hyperhidrosis treatment

excessive sweating treatments

There are various oral medications available known to be prescribed by some doctors to help treat hyperhidrosis.

Ditropan, Robinul, Probanthine

All these oral medications are from the same family of drugs. They have an anti cholinergic effect which in essence blocks the neuro transmission responsible for the production of sweat. The original function of these medications was to help with the treatment of gastric (stomach) ulcers. All of these medications are not specifically for hyperhidrosis but have been known to have the side effect of dryness. Among other side effects they can cause blurry vision, dry mouth, etc. The success rate is known to be very limited.

Have a look at some of the company web sites

Ditropan Website

Robinul Website

Gov Info Website

Other oral medications people use are mild sedatives for example Xanax. This is a very non specific medication that sometimes reduces the sympathetic overtone. Another type of medications being used is a group of medications known as beta blockers. Those medications are being used in the treatment of certain cardiac problems such as hypertension. They may also have some sedative effect on the adrenergic system which plays a role in the production of excessive hand sweating/palmar hyperhidrosis.

***As always consult with your doctor first when considering any treatment

The Future of Oral Medications for Hyperhidrosis

The future of oral medication treatment for hyperhidrosis will occur if scientists are able to find a specific medication that will prevent the release of the hormone (the neurotransmitter Acetyl Choline) that triggers the sweat gland to release sweat. As long as this medication is still not available then we are left with the current medications which are very non-specific.

Have a question or a comment? Please post it below and we will try and answer!


I take a high dose of oxycontin for chronic back pain but the side effect of the excessive sweating is horrendous and is really depressing what can i do apart from lowering drugs which i cant.

Any drug taken by any individual has positive effects as well as negative side effects. Each person will react differently for any given drug. In your particular situation I don't have the privilege of knowing your complete medical history, surgeries, body height and weight ratio etc. Oxycontin being a very strong medication can cause excessive sweating especially when it is taken with other medications as well. I believe that you suffer from total body sweating and not limited to the hands and feet so obviously no surgical solution will be recommended to you.

Hello i am currently on a fentanyl patch for chronic pain would taking a oral medicne for hyperhidrosis help with the sweating?

Hello Tami, different types of pain medications including fentanyl are known to cause sweating. It is a well documented complaint from patients who suffer from chronic pain and use different combinations of pain medication. The exact mechanism for their sweating it not known and adding anti sweating medications could be of help. You should discuss with a pharmacist if there is any contra indication to add the anti sweat medications to the current drug regimen you are on.

I am on a high amount of OxyContin and also meds for heart issues, the last months or so I have been sweating for no reason. Once I start sweat it takes me quite awhile to stop, all I have to do is
a little something extra walking, work around the house etc etc and I just sweat like a stuffed pig.
I have been reading it could be the pain meds but I have been on these meds for about 10 years now and the sweating has only just started. Any thoughts on how to get it under control??

From reading your comment/question I realize that you have two issues at hand. One of them is the usage of oxycontin which alone can cause excessive sweating. The fact that for the last ten years you did not have any problem with that medication does not mean that the chronic use of this medication cannot cause changes in certain receptors of your sweat control mechanism and hence developing sweat on a very easy physical exertion. Also the fact that you mentioned heart issues also means that your body is aging and certain physiological functions are changing with it. Obviously not knowing your whole medical background makes it difficult for me to give you a definite answer but at least I have tried.

In 2008 I underwent surgery for excessive sweating of the underarms, everything went very well for about a year and a half. During 2010 I was diagnosed with Bipolar depression and started using anti-depressants and mood stabilizers, I stopped using the anti- depressants by myself and started sweating all over my body, face, head and armpits. Is there anything I can use to help with the sweating or was it because of the anti-depressants.

Thanks for your comment. From what you described, I do not have any idea what kind of surgery was performed on you. Was it ETS for axillary sweating or axillary suction curretage. Once an answer is given to this question then a better reply can be provided. Just to mention that the usage of anti depressant drugs by itself can cause excessive sweating. Even though you stopped those, more time may be needed to stabilize your responses.

I have beeen using roaccutane for thelast 3 months, and I'm a person with hyperhidrosis. I sweat a lot in my hands, feet and underarms. Can I use any oral medication like robinol while I'm on Accutane?


With regard to the simultaneous use Accutane and Robinol or other anticholinergic agents you will have to discuss it with your pharmacist to ensure there are no conflicts. The pharmacist will know whether the medications are compatible or not. Basically speaking the efficacy of anticholinergic medications in the treatment of severe cases of palmar or plantar hyperhidrosis is very limited. A trial of using them should not hurt you. Good luck.

I have read many articles online about using Oxybutynin for treatment, and several clinical trials have been done that have had very positive results. I am emailing some of these articles to my primary care physician, hoping she will try me on it. Some of the products can be purchased over the counter, but I prefer to have it prescribed in the extended release capsules. Are you familiar with Oxybutynin as a treatment for Hyperhidrosis?

Ditropan or Oxybutynin is one of the anti-cholinergic drugs used in the trials to control excessive hands and feet sweating. Some trials showed a limited success rate but it can be tried. There are some side effects such as dry mouth or blurry vision but in small dosages the patient might not suffer from those. Again the response can be different from one person to the next.

Hi, any remedy for excessive sweating on my entire head, face and neck. It looks as though I have just got out the shower. Perspiration pours down my face, hair and neck onto my back and front body. I do not perspire anywhere else on my body. I cannot take heat. In very cold conditions I do not wear a jersey, I get too hot. Please.... any help or medicine you could suggest will be appreciated. The only medication I take is - Ridaq 25mg, Iron Tablets and Magnesium Tablets.

There are several oral medications on the market to treat excessive hand and feet sweating. The most common ones are listed on this page above. Those medications were not created specifically for hyperhidrosis but are known to have some degree of success even though it is very minimal. Ridaq is one of those medications without known specific action for hyperhidrosis. The fact that you get some relief from that is unknown to us. The future of oral medication treatment for hyperhidrosis will likely occur when a specific medication comes that will block the neurotransmitter for the production of sweat.

I had ETS done about 18 years ago on my hands & armpits. I now suffer from compensatory sweating all over my body. I am currently taking Setraline for depression. Would taking Ditropan or similar help my condition? Would it be safe to take with my current medication?

Hoping there will one day be a prescription for hyperhidrosis. Do you see that happening?

Please see above "The Future of Oral Medications for Hyperhidrosis"

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